Bioinformatics Research:
Protein Folding, Docking and Prediction of Biological Activity

Center for Advanced Bioinformatics Research
South-West University "Neofit Rilski", Blagoevgrad



Work programme - FIRST STAGE

1 Installing the necessary software packages and operating systems. 4 Availability of software packages and operating systems.
2 Modeling and optimizing the structure of mu-, delta-and kappa-opioid, neurotensin and cannabinoid receptors. 12 Model of the structure of the mu-, delta-and kappa-opioid receptors, and more recent nevrotenzi cannabinoid receptors.
3 Determining the structure of the ligand-receptor complex and the minimum free energy of binding at the known structures of the receptor and the ligand. 6 Determining the structure of the ligand-receptor complex and the minimum free energy of binding at the known structures. of the receptor and ligand.
4 Create virtual modules for scientific tasks provided by the project. 6 Implementation of server virtualization.
5 Study the applicability of cloud structures and server virtualization tasks in protein folding, docking and determination of biological activity. 6 Preparing a report on the feasibility of cloud structures and server virtualization tasks in protein folding, docking and determination of biological activity.
6 Study the binding mode of the ligand to the receptor in order to propose modifications to the ligands. 6 New modifications of the ligands.
7 Creating a web portal with the possibility of publishing the results of the project. 6 Functioning WEB site of the project.